Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
Identifieur interne : 000114 ( Main/Exploration ); précédent : 000113; suivant : 000115Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
Auteurs : Ferrán Catalá-L Pez [Espagne] ; Brian Hutton ; Jane A. Driver [États-Unis] ; Matthew J. Page [Royaume-Uni] ; Manuel Ridao [Espagne] ; José M. Valderas [Royaume-Uni] ; Adolfo Alonso-Arroyo [Espagne] ; Jaume Forés-Martos [Espagne] ; Salvador Martínez [Espagne] ; Ricard Gènova-Maleras [Espagne] ; Diego Macías-Saint-Gerons [Espagne, États-Unis] ; Benedicto Crespo-Facorro [Espagne] ; Eduard Vieta [Espagne] ; Alfonso Valencia [Espagne] ; Rafael Tabarés-Seisdedos [Espagne]Source :
- Systematic Reviews [ 2046-4053 ] ; 2017.
Abstract
The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.
We will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies. In addition, online databases will be checked for observational studies published outside the time frames of previous reviews. Eligible central nervous system disorders will be Alzheimer’s disease, anorexia nervosa, amyotrophic lateral sclerosis, autism spectrum disorders, bipolar disorder, depression, Down’s syndrome, epilepsy, Huntington’s disease, multiple sclerosis, Parkinson’s disease and schizophrenia. The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder. Secondary outcome measures will be site-specific cancer incidence and mortality, respectively. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study quality/risk of bias will be appraised by two reviewers independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary observational studies will be conducted where appropriate. Parameters for exploring statistical heterogeneity are pre-specified. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes.
Our study will establish the extent of the epidemiological evidence underlying the associations between central nervous system disorders and cancer and will provide a rigorous and updated synthesis of a range of important site-specific cancer outcomes.
PROSPERO CRD42016052762
The online version of this article (doi:10.1186/s13643-017-0466-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13643-017-0466-y
PubMed: 28376926
PubMed Central: 5379758
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000270
- to stream Pmc, to step Curation: 000270
- to stream Pmc, to step Checkpoint: 000023
- to stream Ncbi, to step Merge: 002263
- to stream Ncbi, to step Curation: 002263
- to stream Ncbi, to step Checkpoint: 002263
- to stream Main, to step Merge: 000114
- to stream Main, to step Curation: 000114
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies</title><author><name sortKey="Catala L Pez, Ferran" sort="Catala L Pez, Ferran" uniqKey="Catala L Pez F" first="Ferrán" last="Catalá-L Pez">Ferrán Catalá-L Pez</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Fundación Instituto de Investigación en Servicios de Salud, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Instituto de Investigación en Servicios de Salud, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412687.e</institution-id><institution>Clinical Epidemiology Program,</institution><institution>Ottawa Hospital Research Institute,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Hutton, Brian" sort="Hutton, Brian" uniqKey="Hutton B" first="Brian" last="Hutton">Brian Hutton</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412687.e</institution-id><institution>Clinical Epidemiology Program,</institution><institution>Ottawa Hospital Research Institute,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>School of Epidemiology, Public Health and Preventive Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Driver, Jane A" sort="Driver, Jane A" uniqKey="Driver J" first="Jane A." last="Driver">Jane A. Driver</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.410370.1</institution-id><institution>Geriatric Research Education and Clinical Center,</institution><institution>VA Boston Healthcare System,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Aging, Department of Medicine, Brigham and Women’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Page, Matthew J" sort="Page, Matthew J" uniqKey="Page M" first="Matthew J." last="Page">Matthew J. Page</name><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>School of Public Health and Preventive Medicine,</institution><institution>Monash University,</institution></institution-wrap>Melbourne, Victoria Australia</nlm:aff><wicri:noCountry code="subfield">Victoria Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.5337.2</institution-id><institution></institution><institution>School of Social and Community Medicine, University of Bristol,</institution></institution-wrap>Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Ridao, Manuel" sort="Ridao, Manuel" uniqKey="Ridao M" first="Manuel" last="Ridao">Manuel Ridao</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Instituto Aragonés de Ciencias de la Salud, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Aragonés de Ciencias de la Salud, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.428862.2</institution-id><institution></institution><institution>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Salud Pública),</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Valderas, Jose M" sort="Valderas, Jose M" uniqKey="Valderas J" first="José M." last="Valderas">José M. Valderas</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.8391.3</institution-id><institution>Health Services and Policy Research Group, Exeter Collaboration for Academic Primary Care,</institution><institution>University of Exeter Medical School, University of Exeter,</institution></institution-wrap>Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Alonso Arroyo, Adolfo" sort="Alonso Arroyo, Adolfo" uniqKey="Alonso Arroyo A" first="Adolfo" last="Alonso-Arroyo">Adolfo Alonso-Arroyo</name><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="GRID">grid.5338.d</institution-id><institution>Department of History of Science and Documentation,</institution><institution>University of Valencia,</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="GRID">grid.4711.3</institution-id><institution>Unidad de Información e Investigación Social y Sanitaria-UISYS,</institution><institution>University of Valencia-Spanish National Research Council (CSIC),</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Fores Martos, Jaume" sort="Fores Martos, Jaume" uniqKey="Fores Martos J" first="Jaume" last="Forés-Martos">Jaume Forés-Martos</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Salvador" sort="Martinez, Salvador" uniqKey="Martinez S" first="Salvador" last="Martínez">Salvador Martínez</name><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="GRID">grid.26811.3c</institution-id><institution>Instituto de Neurociencias de Alicante,</institution><institution>Universidad Miguel Hernández-Spanish National Research Council (UMH-CSIC),</institution></institution-wrap>San Juan de Alicante, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>San Juan de Alicante</wicri:regionArea></affiliation></author><author><name sortKey="Genova Maleras, Ricard" sort="Genova Maleras, Ricard" uniqKey="Genova Maleras R" first="Ricard" last="Gènova-Maleras">Ricard Gènova-Maleras</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Directorate General for Public Health, Regional Health Council, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Directorate General for Public Health, Regional Health Council, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Macias Saint Gerons, Diego" sort="Macias Saint Gerons, Diego" uniqKey="Macias Saint Gerons D" first="Diego" last="Macías-Saint-Gerons">Diego Macías-Saint-Gerons</name><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="GRID">grid.443875.9</institution-id><institution>Division of Pharmacoepidemiology and Pharmacovigilance,</institution><institution>Spanish Medicines and Healthcare Products Agency (AEMPS),</institution></institution-wrap>Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Madrid</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="GRID">grid.4437.4</institution-id><institution>Department of Health Systems and Services, Unit of Medicines and Health Technologies,</institution><institution>Pan American Health Organization (PAHO),</institution></institution-wrap>Washington, DC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Washington</wicri:cityArea></affiliation></author><author><name sortKey="Crespo Facorro, Benedicto" sort="Crespo Facorro, Benedicto" uniqKey="Crespo Facorro B" first="Benedicto" last="Crespo-Facorro">Benedicto Crespo-Facorro</name><affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="GRID">grid.411325.0</institution-id><institution>Department of Psychiatry,</institution><institution>Hospital Marqués de Valdecilla, University of Cantabria/IDIVAL and CIBERSAM,</institution></institution-wrap>Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Santander</wicri:regionArea></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="GRID">grid.5841.8</institution-id><institution>Hospital Clínic,</institution><institution>Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and CIBERSAM,</institution></institution-wrap>Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="1"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="GRID">grid.7719.8</institution-id><institution>Structural Biology and Biocumputing Programme,</institution><institution>Spanish National Cancer Research Centre (CNIO),</institution></institution-wrap>Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="GRID">grid.10097.3f</institution-id><institution>Life Sciences Department,</institution><institution>Barcelona Supercomputing Center,</institution></institution-wrap>Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28376926</idno><idno type="pmc">5379758</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379758</idno><idno type="RBID">PMC:5379758</idno><idno type="doi">10.1186/s13643-017-0466-y</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000270</idno><idno type="wicri:Area/Pmc/Curation">000270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000270</idno><idno type="wicri:Area/Pmc/Checkpoint">000023</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000023</idno><idno type="wicri:Area/Ncbi/Merge">002263</idno><idno type="wicri:Area/Ncbi/Curation">002263</idno><idno type="wicri:Area/Ncbi/Checkpoint">002263</idno><idno type="wicri:Area/Main/Merge">000114</idno><idno type="wicri:Area/Main/Curation">000114</idno><idno type="wicri:Area/Main/Exploration">000114</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies</title><author><name sortKey="Catala L Pez, Ferran" sort="Catala L Pez, Ferran" uniqKey="Catala L Pez F" first="Ferrán" last="Catalá-L Pez">Ferrán Catalá-L Pez</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Fundación Instituto de Investigación en Servicios de Salud, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Instituto de Investigación en Servicios de Salud, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412687.e</institution-id><institution>Clinical Epidemiology Program,</institution><institution>Ottawa Hospital Research Institute,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Hutton, Brian" sort="Hutton, Brian" uniqKey="Hutton B" first="Brian" last="Hutton">Brian Hutton</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412687.e</institution-id><institution>Clinical Epidemiology Program,</institution><institution>Ottawa Hospital Research Institute,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>School of Epidemiology, Public Health and Preventive Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Driver, Jane A" sort="Driver, Jane A" uniqKey="Driver J" first="Jane A." last="Driver">Jane A. Driver</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.410370.1</institution-id><institution>Geriatric Research Education and Clinical Center,</institution><institution>VA Boston Healthcare System,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Aging, Department of Medicine, Brigham and Women’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Page, Matthew J" sort="Page, Matthew J" uniqKey="Page M" first="Matthew J." last="Page">Matthew J. Page</name><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>School of Public Health and Preventive Medicine,</institution><institution>Monash University,</institution></institution-wrap>Melbourne, Victoria Australia</nlm:aff><wicri:noCountry code="subfield">Victoria Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.5337.2</institution-id><institution></institution><institution>School of Social and Community Medicine, University of Bristol,</institution></institution-wrap>Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Ridao, Manuel" sort="Ridao, Manuel" uniqKey="Ridao M" first="Manuel" last="Ridao">Manuel Ridao</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Instituto Aragonés de Ciencias de la Salud, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Aragonés de Ciencias de la Salud, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.428862.2</institution-id><institution></institution><institution>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Salud Pública),</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Valderas, Jose M" sort="Valderas, Jose M" uniqKey="Valderas J" first="José M." last="Valderas">José M. Valderas</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.8391.3</institution-id><institution>Health Services and Policy Research Group, Exeter Collaboration for Academic Primary Care,</institution><institution>University of Exeter Medical School, University of Exeter,</institution></institution-wrap>Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Alonso Arroyo, Adolfo" sort="Alonso Arroyo, Adolfo" uniqKey="Alonso Arroyo A" first="Adolfo" last="Alonso-Arroyo">Adolfo Alonso-Arroyo</name><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="GRID">grid.5338.d</institution-id><institution>Department of History of Science and Documentation,</institution><institution>University of Valencia,</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="GRID">grid.4711.3</institution-id><institution>Unidad de Información e Investigación Social y Sanitaria-UISYS,</institution><institution>University of Valencia-Spanish National Research Council (CSIC),</institution></institution-wrap>Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Fores Martos, Jaume" sort="Fores Martos, Jaume" uniqKey="Fores Martos J" first="Jaume" last="Forés-Martos">Jaume Forés-Martos</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Salvador" sort="Martinez, Salvador" uniqKey="Martinez S" first="Salvador" last="Martínez">Salvador Martínez</name><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="GRID">grid.26811.3c</institution-id><institution>Instituto de Neurociencias de Alicante,</institution><institution>Universidad Miguel Hernández-Spanish National Research Council (UMH-CSIC),</institution></institution-wrap>San Juan de Alicante, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>San Juan de Alicante</wicri:regionArea></affiliation></author><author><name sortKey="Genova Maleras, Ricard" sort="Genova Maleras, Ricard" uniqKey="Genova Maleras R" first="Ricard" last="Gènova-Maleras">Ricard Gènova-Maleras</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Directorate General for Public Health, Regional Health Council, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Directorate General for Public Health, Regional Health Council, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Macias Saint Gerons, Diego" sort="Macias Saint Gerons, Diego" uniqKey="Macias Saint Gerons D" first="Diego" last="Macías-Saint-Gerons">Diego Macías-Saint-Gerons</name><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="GRID">grid.443875.9</institution-id><institution>Division of Pharmacoepidemiology and Pharmacovigilance,</institution><institution>Spanish Medicines and Healthcare Products Agency (AEMPS),</institution></institution-wrap>Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Madrid</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="GRID">grid.4437.4</institution-id><institution>Department of Health Systems and Services, Unit of Medicines and Health Technologies,</institution><institution>Pan American Health Organization (PAHO),</institution></institution-wrap>Washington, DC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Washington</wicri:cityArea></affiliation></author><author><name sortKey="Crespo Facorro, Benedicto" sort="Crespo Facorro, Benedicto" uniqKey="Crespo Facorro B" first="Benedicto" last="Crespo-Facorro">Benedicto Crespo-Facorro</name><affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="GRID">grid.411325.0</institution-id><institution>Department of Psychiatry,</institution><institution>Hospital Marqués de Valdecilla, University of Cantabria/IDIVAL and CIBERSAM,</institution></institution-wrap>Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Santander</wicri:regionArea></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="GRID">grid.5841.8</institution-id><institution>Hospital Clínic,</institution><institution>Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and CIBERSAM,</institution></institution-wrap>Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="1"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="GRID">grid.7719.8</institution-id><institution>Structural Biology and Biocumputing Programme,</institution><institution>Spanish National Cancer Research Centre (CNIO),</institution></institution-wrap>Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="GRID">grid.10097.3f</institution-id><institution>Life Sciences Department,</institution><institution>Barcelona Supercomputing Center,</institution></institution-wrap>Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Systematic Reviews</title><idno type="eISSN">2046-4053</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.</p></sec><sec><title>Methods/design</title><p>We will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies. In addition, online databases will be checked for observational studies published outside the time frames of previous reviews. Eligible central nervous system disorders will be Alzheimer’s disease, anorexia nervosa, amyotrophic lateral sclerosis, autism spectrum disorders, bipolar disorder, depression, Down’s syndrome, epilepsy, Huntington’s disease, multiple sclerosis, Parkinson’s disease and schizophrenia. The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder. Secondary outcome measures will be site-specific cancer incidence and mortality, respectively. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study quality/risk of bias will be appraised by two reviewers independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary observational studies will be conducted where appropriate. Parameters for exploring statistical heterogeneity are pre-specified. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes.</p></sec><sec><title>Discussion</title><p>Our study will establish the extent of the epidemiological evidence underlying the associations between central nervous system disorders and cancer and will provide a rigorous and updated synthesis of a range of important site-specific cancer outcomes.</p></sec><sec><title>Systematic review registration</title><p>PROSPERO CRD42016052762</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13643-017-0466-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Genova Maleras, R" uniqKey="Genova Maleras R">R Gènova-Maleras</name></author><author><name sortKey="Vieta, E" uniqKey="Vieta E">E Vieta</name></author><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Atun, R" uniqKey="Atun R">R Atun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, E" uniqKey="Wallace E">E Wallace</name></author><author><name sortKey="Salisbury, C" uniqKey="Salisbury C">C Salisbury</name></author><author><name sortKey="Guthrie, B" uniqKey="Guthrie B">B Guthrie</name></author><author><name sortKey="Lewis, C" uniqKey="Lewis C">C Lewis</name></author><author><name sortKey="Fahey, T" uniqKey="Fahey T">T Fahey</name></author><author><name sortKey="Smith, Sm" uniqKey="Smith S">SM Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnett, K" uniqKey="Barnett K">K Barnett</name></author><author><name sortKey="Mercer, Sw" uniqKey="Mercer S">SW Mercer</name></author><author><name sortKey="Norbury, M" uniqKey="Norbury M">M Norbury</name></author><author><name sortKey="Watt, G" uniqKey="Watt G">G Watt</name></author><author><name sortKey="Wyke, S" uniqKey="Wyke S">S Wyke</name></author><author><name sortKey="Guthrie, B" uniqKey="Guthrie B">B Guthrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, Jh" uniqKey="Olsen J">JH Olsen</name></author><author><name sortKey="Friis, S" uniqKey="Friis S">S Friis</name></author><author><name sortKey="Frederiksen, K" uniqKey="Frederiksen K">K Frederiksen</name></author><author><name sortKey="Mclaughlin, Jk" uniqKey="Mclaughlin J">JK McLaughlin</name></author><author><name sortKey="Mellemkjaer, L" uniqKey="Mellemkjaer L">L Mellemkjaer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rugbjerg, K" uniqKey="Rugbjerg K">K Rugbjerg</name></author><author><name sortKey="Friis, S" uniqKey="Friis S">S Friis</name></author><author><name sortKey="Lassen, Cf" uniqKey="Lassen C">CF Lassen</name></author><author><name sortKey="Ritz, B" uniqKey="Ritz B">B Ritz</name></author><author><name sortKey="Olsen, Jh" uniqKey="Olsen J">JH Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahmanyar, S" uniqKey="Bahmanyar S">S Bahmanyar</name></author><author><name sortKey="Montgomery, Sm" uniqKey="Montgomery S">SM Montgomery</name></author><author><name sortKey="Hillert, J" uniqKey="Hillert J">J Hillert</name></author><author><name sortKey="Ekbom, A" uniqKey="Ekbom A">A Ekbom</name></author><author><name sortKey="Olsson, T" uniqKey="Olsson T">T Olsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fois, Af" uniqKey="Fois A">AF Fois</name></author><author><name sortKey="Wotton, Cj" uniqKey="Wotton C">CJ Wotton</name></author><author><name sortKey="Yeates, D" uniqKey="Yeates D">D Yeates</name></author><author><name sortKey="Turner, Mr" uniqKey="Turner M">MR Turner</name></author><author><name sortKey="Goldacre, Mj" uniqKey="Goldacre M">MJ Goldacre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catts, Vs" uniqKey="Catts V">VS Catts</name></author><author><name sortKey="Catts, Sv" uniqKey="Catts S">SV Catts</name></author><author><name sortKey="O Oole, Bi" uniqKey="O Oole B">BI O’Toole</name></author><author><name sortKey="Frost, Ad" uniqKey="Frost A">AD Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bushe, Cj" uniqKey="Bushe C">CJ Bushe</name></author><author><name sortKey="Bradley, Aj" uniqKey="Bradley A">AJ Bradley</name></author><author><name sortKey="Wildgust, Hj" uniqKey="Wildgust H">HJ Wildgust</name></author><author><name sortKey="Hodgson, Re" uniqKey="Hodgson R">RE Hodgson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Suarez Pinilla, M" uniqKey="Suarez Pinilla M">M Suárez-Pinilla</name></author><author><name sortKey="Suarez Pinilla, P" uniqKey="Suarez Pinilla P">P Suárez-Pinilla</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="G Mez Beneyto, M" uniqKey="G Mez Beneyto M">M Gómez-Beneyto</name></author><author><name sortKey="Martinez, S" uniqKey="Martinez S">S Martínez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Dumont, N" uniqKey="Dumont N">N Dumont</name></author><author><name sortKey="Baudot, A" uniqKey="Baudot A">A Baudot</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Climent, J" uniqKey="Climent J">J Climent</name></author><author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Miller, Jp" uniqKey="Miller J">JP Miller</name></author><author><name sortKey="Morris, Jc" uniqKey="Morris J">JC Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Fitzpatrick, Al" uniqKey="Fitzpatrick A">AL Fitzpatrick</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Sieh, W" uniqKey="Sieh W">W Sieh</name></author><author><name sortKey="Kuller, L" uniqKey="Kuller L">L Kuller</name></author><author><name sortKey="Miller, Jp" uniqKey="Miller J">JP Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Beiser, A" uniqKey="Beiser A">A Beiser</name></author><author><name sortKey="Au, R" uniqKey="Au R">R Au</name></author><author><name sortKey="Kreger, Be" uniqKey="Kreger B">BE Kreger</name></author><author><name sortKey="Splansky, Gl" uniqKey="Splansky G">GL Splansky</name></author><author><name sortKey="Kurth, T" uniqKey="Kurth T">T Kurth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musicco, M" uniqKey="Musicco M">M Musicco</name></author><author><name sortKey="Adorni, F" uniqKey="Adorni F">F Adorni</name></author><author><name sortKey="Di Santo, S" uniqKey="Di Santo S">S Di Santo</name></author><author><name sortKey="Prinelli, F" uniqKey="Prinelli F">F Prinelli</name></author><author><name sortKey="Pettenati, C" uniqKey="Pettenati C">C Pettenati</name></author><author><name sortKey="Caltagirone, C" uniqKey="Caltagirone C">C Caltagirone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Crespo Facorro, B" uniqKey="Crespo Facorro B">B Crespo-Facorro</name></author><author><name sortKey="Vieta, E" uniqKey="Vieta E">E Vieta</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name></author><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Guo, S" uniqKey="Guo S">S Guo</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Tang, S" uniqKey="Tang S">S Tang</name></author><author><name sortKey="Shao, W" uniqKey="Shao W">W Shao</name></author><author><name sortKey="Han, X" uniqKey="Han X">X Han</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Logroscino, G" uniqKey="Logroscino G">G Logroscino</name></author><author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name></author><author><name sortKey="Gaziano, Jm" uniqKey="Gaziano J">JM Gaziano</name></author><author><name sortKey="Kurth, T" uniqKey="Kurth T">T Kurth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elbaz, A" uniqKey="Elbaz A">A Elbaz</name></author><author><name sortKey="Peterson, Bj" uniqKey="Peterson B">BJ Peterson</name></author><author><name sortKey="Bower, Jh" uniqKey="Bower J">JH Bower</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name></author><author><name sortKey="Maraganore, Dm" uniqKey="Maraganore D">DM Maraganore</name></author><author><name sortKey="Mcdonnell, Sk" uniqKey="Mcdonnell S">SK McDonnell</name></author><author><name sortKey="Ahlskog, Je" uniqKey="Ahlskog J">JE Ahlskog</name></author><author><name sortKey="Rocca, Wa" uniqKey="Rocca W">WA Rocca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bajaj, A" uniqKey="Bajaj A">A Bajaj</name></author><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Schernhammer, Es" uniqKey="Schernhammer E">ES Schernhammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Rubenstein, Jl" uniqKey="Rubenstein J">JL Rubenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iba Ez, K" uniqKey="Iba Ez K">K Ibáñez</name></author><author><name sortKey="Boullosa, C" uniqKey="Boullosa C">C Boullosa</name></author><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Baudot, A" uniqKey="Baudot A">A Baudot</name></author><author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyzas, Pa" uniqKey="Kyzas P">PA Kyzas</name></author><author><name sortKey="Loizou, Kt" uniqKey="Loizou K">KT Loizou</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyzas, Pa" uniqKey="Kyzas P">PA Kyzas</name></author><author><name sortKey="Denaxa Kyza, D" uniqKey="Denaxa Kyza D">D Denaxa-Kyza</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsilidis, Kk" uniqKey="Tsilidis K">KK Tsilidis</name></author><author><name sortKey="Papatheodorou, Si" uniqKey="Papatheodorou S">SI Papatheodorou</name></author><author><name sortKey="Evangelou, E" uniqKey="Evangelou E">E Evangelou</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Chang, Cq" uniqKey="Chang C">CQ Chang</name></author><author><name sortKey="Schully, Sd" uniqKey="Schully S">SD Schully</name></author><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name></author><author><name sortKey="Freedman, An" uniqKey="Freedman A">AN Freedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsilidis, Kk" uniqKey="Tsilidis K">KK Tsilidis</name></author><author><name sortKey="Kasimis, Jc" uniqKey="Kasimis J">JC Kasimis</name></author><author><name sortKey="Lopez, Ds" uniqKey="Lopez D">DS Lopez</name></author><author><name sortKey="Ntzani, Ee" uniqKey="Ntzani E">EE Ntzani</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raviv, G" uniqKey="Raviv G">G Raviv</name></author><author><name sortKey="Laufer, M" uniqKey="Laufer M">M Laufer</name></author><author><name sortKey="Baruch, Y" uniqKey="Baruch Y">Y Baruch</name></author><author><name sortKey="Barak, Y" uniqKey="Barak Y">Y Barak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ong, El" uniqKey="Ong E">EL Ong</name></author><author><name sortKey="Goldacre, R" uniqKey="Goldacre R">R Goldacre</name></author><author><name sortKey="Goldacre, M" uniqKey="Goldacre M">M Goldacre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, Hl" uniqKey="Chiang H">HL Chiang</name></author><author><name sortKey="Liu, Cj" uniqKey="Liu C">CJ Liu</name></author><author><name sortKey="Hu, Yw" uniqKey="Hu Y">YW Hu</name></author><author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name></author><author><name sortKey="Hu, Ly" uniqKey="Hu L">LY Hu</name></author><author><name sortKey="Shen, Cc" uniqKey="Shen C">CC Shen</name></author><author><name sortKey="Yeh, Cm" uniqKey="Yeh C">CM Yeh</name></author><author><name sortKey="Chen, Tj" uniqKey="Chen T">TJ Chen</name></author><author><name sortKey="Gau, Ss" uniqKey="Gau S">SS Gau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olfson, M" uniqKey="Olfson M">M Olfson</name></author><author><name sortKey="Gerhard, T" uniqKey="Gerhard T">T Gerhard</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Crystal, S" uniqKey="Crystal S">S Crystal</name></author><author><name sortKey="Stroup, Ts" uniqKey="Stroup T">TS Stroup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Py" uniqKey="Lin P">PY Lin</name></author><author><name sortKey="Chang, Sn" uniqKey="Chang S">SN Chang</name></author><author><name sortKey="Hsiao, Th" uniqKey="Hsiao T">TH Hsiao</name></author><author><name sortKey="Huang, Bt" uniqKey="Huang B">BT Huang</name></author><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Yang, Pc" uniqKey="Yang P">PC Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Cf" uniqKey="Tang C">CF Tang</name></author><author><name sortKey="Lu, Mk" uniqKey="Lu M">MK Lu</name></author><author><name sortKey="Muo, Ch" uniqKey="Muo C">CH Muo</name></author><author><name sortKey="Tsai, Ch" uniqKey="Tsai C">CH Tsai</name></author><author><name sortKey="Kao, Ch" uniqKey="Kao C">CH Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Shamseer, L" uniqKey="Shamseer L">L Shamseer</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Ghersi, D" uniqKey="Ghersi D">D Ghersi</name></author><author><name sortKey="Liberati, A" uniqKey="Liberati A">A Liberati</name></author><author><name sortKey="Petticrew, M" uniqKey="Petticrew M">M Petticrew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shamseer, L" uniqKey="Shamseer L">L Shamseer</name></author><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Ghersi, D" uniqKey="Ghersi D">D Ghersi</name></author><author><name sortKey="Liberati, A" uniqKey="Liberati A">A Liberati</name></author><author><name sortKey="Petticrew, M" uniqKey="Petticrew M">M Petticrew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theodoratou, E" uniqKey="Theodoratou E">E Theodoratou</name></author><author><name sortKey="Tzoulaki, I" uniqKey="Tzoulaki I">I Tzoulaki</name></author><author><name sortKey="Zgaga, L" uniqKey="Zgaga L">L Zgaga</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belbasis, L" uniqKey="Belbasis L">L Belbasis</name></author><author><name sortKey="Bellou, V" uniqKey="Bellou V">V Bellou</name></author><author><name sortKey="Evangelou, E" uniqKey="Evangelou E">E Evangelou</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Tzoulaki, I" uniqKey="Tzoulaki I">I Tzoulaki</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fitzmaurice, C" uniqKey="Fitzmaurice C">C Fitzmaurice</name></author><author><name sortKey="Dicker, D" uniqKey="Dicker D">D Dicker</name></author><author><name sortKey="Pain, A" uniqKey="Pain A">A Pain</name></author><author><name sortKey="Hamavid, H" uniqKey="Hamavid H">H Hamavid</name></author><author><name sortKey="Moradi Lakeh, M" uniqKey="Moradi Lakeh M">M Moradi-Lakeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sampson, M" uniqKey="Sampson M">M Sampson</name></author><author><name sortKey="Shojania, Kg" uniqKey="Shojania K">KG Shojania</name></author><author><name sortKey="Mcgowan, J" uniqKey="Mcgowan J">J McGowan</name></author><author><name sortKey="Daniel, R" uniqKey="Daniel R">R Daniel</name></author><author><name sortKey="Rader, T" uniqKey="Rader T">T Rader</name></author><author><name sortKey="Iansavichene, Ae" uniqKey="Iansavichene A">AE Iansavichene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutton, B" uniqKey="Hutton B">B Hutton</name></author><author><name sortKey="Tetzlaff, J" uniqKey="Tetzlaff J">J Tetzlaff</name></author><author><name sortKey="Yazdi, F" uniqKey="Yazdi F">F Yazdi</name></author><author><name sortKey="Thielman, J" uniqKey="Thielman J">J Thielman</name></author><author><name sortKey="Kanji, S" uniqKey="Kanji S">S Kanji</name></author><author><name sortKey="Fergusson, D" uniqKey="Fergusson D">D Fergusson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Hutton, B" uniqKey="Hutton B">B Hutton</name></author><author><name sortKey="Nu Ez Beltran, A" uniqKey="Nu Ez Beltran A">A Núñez-Beltrán</name></author><author><name sortKey="Mayhew, Ad" uniqKey="Mayhew A">AD Mayhew</name></author><author><name sortKey="Page, Mj" uniqKey="Page M">MJ Page</name></author><author><name sortKey="Ridao, M" uniqKey="Ridao M">M Ridao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Macias Saint Gerons, D" uniqKey="Macias Saint Gerons D">D Macías Saint-Gerons</name></author><author><name sortKey="Gonzalez Bermejo, D" uniqKey="Gonzalez Bermejo D">D González-Bermejo</name></author><author><name sortKey="Rosano, Gm" uniqKey="Rosano G">GM Rosano</name></author><author><name sortKey="Davis, Br" uniqKey="Davis B">BR Davis</name></author><author><name sortKey="Ridao, M" uniqKey="Ridao M">M Ridao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shea, Bj" uniqKey="Shea B">BJ Shea</name></author><author><name sortKey="Grimshaw, Jm" uniqKey="Grimshaw J">JM Grimshaw</name></author><author><name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Andersson, N" uniqKey="Andersson N">N Andersson</name></author><author><name sortKey="Hamel, C" uniqKey="Hamel C">C Hamel</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smith, V" uniqKey="Smith V">V Smith</name></author><author><name sortKey="Devane, D" uniqKey="Devane D">D Devane</name></author><author><name sortKey="Begley, Cm" uniqKey="Begley C">CM Begley</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dersimonian, R" uniqKey="Dersimonian R">R DerSimonian</name></author><author><name sortKey="Laird, N" uniqKey="Laird N">N Laird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cochran, Wg" uniqKey="Cochran W">WG Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Spiegelhalter, Dj" uniqKey="Spiegelhalter D">DJ Spiegelhalter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riley, Rd" uniqKey="Riley R">RD Riley</name></author><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forouzanfar, Mh" uniqKey="Forouzanfar M">MH Forouzanfar</name></author><author><name sortKey="Alexander, L" uniqKey="Alexander L">L Alexander</name></author><author><name sortKey="Anderson, Hr" uniqKey="Anderson H">HR Anderson</name></author><author><name sortKey="Bachman, Vf" uniqKey="Bachman V">VF Bachman</name></author><author><name sortKey="Biryukov, S" uniqKey="Biryukov S">S Biryukov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Guyatt, Gh" uniqKey="Guyatt G">GH Guyatt</name></author><author><name sortKey="Oxman, Ad" uniqKey="Oxman A">AD Oxman</name></author><author><name sortKey="Vist, Ge" uniqKey="Vist G">GE Vist</name></author><author><name sortKey="Kunz, R" uniqKey="Kunz R">R Kunz</name></author><author><name sortKey="Falck Ytter, Y" uniqKey="Falck Ytter Y">Y Falck-Ytter</name></author><author><name sortKey="Alonso Coello, P" uniqKey="Alonso Coello P">P Alonso-Coello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, J" uniqKey="Lau J">J Lau</name></author><author><name sortKey="Antman, Em" uniqKey="Antman E">EM Antman</name></author><author><name sortKey="Jimenez Silva, J" uniqKey="Jimenez Silva J">J Jimenez-Silva</name></author><author><name sortKey="Kupelnick, B" uniqKey="Kupelnick B">B Kupelnick</name></author><author><name sortKey="Mosteller, F" uniqKey="Mosteller F">F Mosteller</name></author><author><name sortKey="Chalmers, Tc" uniqKey="Chalmers T">TC Chalmers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, J" uniqKey="Ioannidis J">J Ioannidis</name></author><author><name sortKey="Lau, J" uniqKey="Lau J">J Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M Schneider</name></author><author><name sortKey="Minder, C" uniqKey="Minder C">C Minder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begg, Cb" uniqKey="Begg C">CB Begg</name></author><author><name sortKey="Mazumdar, M" uniqKey="Mazumdar M">M Mazumdar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmer, Tm" uniqKey="Palmer T">TM Palmer</name></author><author><name sortKey="Sterne, Jac" uniqKey="Sterne J">JAC Sterne</name></author><author><name sortKey="Newton, Hj" uniqKey="Newton H">HJ Newton</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Elm, E" uniqKey="Von Elm E">E von Elm</name></author><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Greenland, S" uniqKey="Greenland S">S Greenland</name></author><author><name sortKey="Hlatky, Ma" uniqKey="Hlatky M">MA Hlatky</name></author><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name></author><author><name sortKey="Macleod, Mr" uniqKey="Macleod M">MR Macleod</name></author><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glasziou, P" uniqKey="Glasziou P">P Glasziou</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Bossuyt, P" uniqKey="Bossuyt P">P Bossuyt</name></author><author><name sortKey="Boutron, I" uniqKey="Boutron I">I Boutron</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Julious, S" uniqKey="Julious S">S Julious</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>District de Columbia</li><li>Massachusetts</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Hutton, Brian" sort="Hutton, Brian" uniqKey="Hutton B" first="Brian" last="Hutton">Brian Hutton</name></noCountry><country name="Espagne"><noRegion><name sortKey="Catala L Pez, Ferran" sort="Catala L Pez, Ferran" uniqKey="Catala L Pez F" first="Ferrán" last="Catalá-L Pez">Ferrán Catalá-L Pez</name></noRegion><name sortKey="Alonso Arroyo, Adolfo" sort="Alonso Arroyo, Adolfo" uniqKey="Alonso Arroyo A" first="Adolfo" last="Alonso-Arroyo">Adolfo Alonso-Arroyo</name><name sortKey="Alonso Arroyo, Adolfo" sort="Alonso Arroyo, Adolfo" uniqKey="Alonso Arroyo A" first="Adolfo" last="Alonso-Arroyo">Adolfo Alonso-Arroyo</name><name sortKey="Catala L Pez, Ferran" sort="Catala L Pez, Ferran" uniqKey="Catala L Pez F" first="Ferrán" last="Catalá-L Pez">Ferrán Catalá-L Pez</name><name sortKey="Crespo Facorro, Benedicto" sort="Crespo Facorro, Benedicto" uniqKey="Crespo Facorro B" first="Benedicto" last="Crespo-Facorro">Benedicto Crespo-Facorro</name><name sortKey="Fores Martos, Jaume" sort="Fores Martos, Jaume" uniqKey="Fores Martos J" first="Jaume" last="Forés-Martos">Jaume Forés-Martos</name><name sortKey="Genova Maleras, Ricard" sort="Genova Maleras, Ricard" uniqKey="Genova Maleras R" first="Ricard" last="Gènova-Maleras">Ricard Gènova-Maleras</name><name sortKey="Macias Saint Gerons, Diego" sort="Macias Saint Gerons, Diego" uniqKey="Macias Saint Gerons D" first="Diego" last="Macías-Saint-Gerons">Diego Macías-Saint-Gerons</name><name sortKey="Martinez, Salvador" sort="Martinez, Salvador" uniqKey="Martinez S" first="Salvador" last="Martínez">Salvador Martínez</name><name sortKey="Ridao, Manuel" sort="Ridao, Manuel" uniqKey="Ridao M" first="Manuel" last="Ridao">Manuel Ridao</name><name sortKey="Ridao, Manuel" sort="Ridao, Manuel" uniqKey="Ridao M" first="Manuel" last="Ridao">Manuel Ridao</name><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Driver, Jane A" sort="Driver, Jane A" uniqKey="Driver J" first="Jane A." last="Driver">Jane A. Driver</name></region><name sortKey="Driver, Jane A" sort="Driver, Jane A" uniqKey="Driver J" first="Jane A." last="Driver">Jane A. Driver</name><name sortKey="Macias Saint Gerons, Diego" sort="Macias Saint Gerons, Diego" uniqKey="Macias Saint Gerons D" first="Diego" last="Macías-Saint-Gerons">Diego Macías-Saint-Gerons</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Page, Matthew J" sort="Page, Matthew J" uniqKey="Page M" first="Matthew J." last="Page">Matthew J. Page</name></noRegion><name sortKey="Valderas, Jose M" sort="Valderas, Jose M" uniqKey="Valderas J" first="José M." last="Valderas">José M. Valderas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000114 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000114 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5379758
|texte= Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28376926" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |